Njira yophatikizira ndi njira zogwirira ntchito za 2-phenylacetamide CAS 103-81-1

Mankhwala: 2-phenylacetamide

Fomula ya maselo: C8H9NO

Molecular kulemera: 135.17

Dzina lachingerezi: Phenylacetamide

Khalidwe: Chotuwa choyera kapena makhiristo ooneka ngati masamba.Mp 157-158 ℃, bp 280-290 ℃ (kuwola).Amasungunuka m'madzi otentha ndi ethanol, amasungunuka pang'ono m'madzi ozizira, ether, ndi benzene.

Kagwiritsidwe: Pakati pa mankhwala monga penicillin ndi phenobarbital.Amagwiritsidwanso ntchito pokonza phenylacetic acid, zonunkhira, ndi mankhwala ophera tizilombo.

Njira 1) Masoko F，Katsura T.US 4536599A1.1985.

Onjezani 117.2 g (1.0 mol) wa phenylacetonitrile (2), 56.1 g wa 25% potaziyamu hydroxide solution, 291.5 g 35% hydrogen peroxide amadzimadzi njira, 1.78 g benzyltriethylammonium kolorayidi, ndi 351.5 magalamu a isopropanoOnetsetsani ndikuchitapo pa 50 ℃ kwa maola 4.Zomwezo zikamalizidwa, isopropanol imapangidwa nthunzi pansi pa kupanikizika kwafupikitsa, utakhazikika, kusefedwa, kutsukidwa ndi madzi, ndikuwumitsa kuti ipeze pawiri (1) 128.5 g, mp 155 ℃, ndi zokolola za 95%.

Njira 2) Furniss BS, Hannaford AJ, Rogers V, ndi al.Vogel's Textbook of Practical Chemistry.Longman London ndi New York.Kusindikiza kwachinayi,1978:518.

Onjezani 100 g (0.85 mol) ya phenylacetonitrile (2) ndi 400 mL ya hydrochloric acid yokhazikika ku botolo lamadzi.Posonkhezera, itani pa 40 ℃ kwa mphindi pafupifupi 40, ndikukweza kutentha mpaka 50 ℃.Pitirizani kuchitapo kanthu kwa mphindi 30.Kuzizira mpaka 15 ℃ ndikuwonjezera 400 ml ya madzi ozizira osungunuka.Kuziziritsa mu madzi osambira oundana, kusefa makhiristo.Onjezerani zolimba ku 50 ml ya madzi ndikugwedeza bwino kuti muchotse phenylacetic acid.Sefa ndi kuumitsa pa 50-80 ℃ kuti mupeze 95 g phenylacetamide (1), mp 154-155 ℃, ndi zokolola za 82%.Recrystallization ndi Mowa, mp 156 ℃.