1,3-Dihydroxyacetone Njira Zopangira ndi Kuyambitsa Ntchito CAS 96-26-4

1,3-Dihydroxyacetone Chiyambi

1,3-Dihydroxyacetone ndi organic pawiri ndi molecular formula C3H6O3, amene ndi polyhydroxyketose ndi ketose yosavuta.Maonekedwe ake ndi kristalo woyera wa ufa, wosungunuka mosavuta mu zosungunulira za organic monga madzi, ethanol, ether, ndi acetone.Malo osungunuka ndi 75-80 ℃, ndipo kusungunuka kwamadzi ndi> 250g/L (20 ℃).Ili ndi kukoma kokoma ndipo imakhala yokhazikika pa pH 6.0.1,3-Dihydroxyacetone ndi shuga wotsika.Ma monosaccharides onse (bola ngati pali magulu a aldehyde aulere kapena ketone carbonyl) amakhala ndi reducibility.Dihydroxyacetone imakwaniritsa zomwe zili pamwambapa, chifukwa chake ndi gulu la kuchepetsa shuga.

Pali makamaka mankhwala kaphatikizidwe njira ndi tizilombo nayonso mphamvu njira.Pali njira zitatu zazikulu zamakina za 1,3-dihydroxyacetone: electrocatalysis, metal catalytic oxidation, ndi formaldehyde condensation.Kupanga mankhwala a 1,3-dihydroxyacetone akadali mu gawo la kafukufuku wa labotale.Kupanga kwa 1,3-dihydroxyacetone mwa njira yachilengedwe kumakhala ndi zabwino zambiri: kukhathamiritsa kwazinthu zambiri, kuchuluka kwa kutembenuka kwa glycerol ndi mtengo wotsika wopanga.Kupanga kwa 1,3-dihydroxyacetone ku China ndi kunja makamaka kumatengera njira yosinthira glycerol.

Chemcial synthesis njira

1. 1,3-dihydroxyacetone imapangidwa kuchokera ku 1,3-dichloroacetone ndi ethylene glycol monga zida zazikulu zopangira carbonyl chitetezo, etherification, hydrogenolysis, ndi hydrolysis.1,3-dichloroacetone ndi ethylene glycol zimatenthedwa ndikusinthidwanso mu toluene kupanga 2,2-dichloromethyl-1,3-dioxolane.Kenako amachitapo kanthu ndi sodium benzylidene mu N, N-dimethylformamide kupanga 2,2-dibenzyloxy-1,3-dioxolane, yomwe imapangidwa ndi hydrogenated pansi pa Pd/C catalysis kuti ipange 1,3-dioxolane-2,2-dimethanol, Kenako imapangidwa ndi hydrolyzed mu hydrochloric acid kuti ipange 1,3-dihydroxyacetone.The zopangira synthesizing 1,3-dihydroxyacetone ntchito njira yosavuta kupeza, zinthu zimene ndi wofatsa, ndi Pd/C chothandizira akhoza zobwezerezedwanso, amene ali ofunika ntchito phindu.

2. 1,3-dihydroxyacetone inapangidwa kuchokera ku 1,3-dichloroacetone ndi methanol kupyolera mu chitetezo cha carbonyl, etherification, hydrolysis, ndi hydrolysis reactions.1,3-dichloroacetone imakhudzidwa ndi methanol yambiri ya anhydrous pamaso pa chotengera kuti chipange 2,2-dimethoxy-1,3-dichloropropane, yomwe imatenthedwa ndi sodium benzylate mu N, N-dimethylformamide kupanga 2,2-dimethoxy. -1,3-dibenzyloxypropane.Ndiye hydrogenated pansi Pd/C catalysis kupanga 2,2-dimethoxy-1,3-propanediol, amene ndiye hydrolyzed mu hydrochloric asidi kupanga 1,3-dihydroxyacetone.Njirayi imalowa m'malo mwa chitetezo cha carbonyl kuchokera ku ethylene glycol kupita ku methanol, zomwe zimapangitsa kuti zikhale zosavuta kupatukana ndi kuyeretsa mankhwala 1,3-dihydroxyacetone, omwe ali ndi chitukuko chofunikira ndi ntchito.

3. Kaphatikizidwe ka 1,3-dihydroxyacetone pogwiritsa ntchito acetone, methanol, chlorine kapena bromine monga zida zazikulu zopangira.Acetone, anhydrous methanol, ndi chlorine gasi kapena bromine amagwiritsidwa ntchito kupanga 2,2-dimethoxy-1,3-dichloropropane kapena 1,3-dibromo-2,2-dimethoxypropane kudzera mumphika umodzi.Iwo ndiye etherified ndi sodium benzylate kupanga 2,2-dimethoxy-1,3-dibenzyloxypropane, amene ndiye hydrogenated ndi hydrolyzed kupanga 1,3-dihydroxyacetone.Njirayi imakhala yocheperako, ndipo "mphika umodzi" umapewa kugwiritsa ntchito 1,3-dichloroacetone yokwera mtengo komanso yokwiyitsa, ndikupangitsa kuti ikhale yotsika mtengo komanso yofunika kwambiri pachitukuko.

Mapulogalamu

1,3-Dihydroxyacetone ndi ketose yochitika mwachilengedwe yomwe imatha kuwonongeka, kudyedwa, komanso yopanda poizoni mthupi la munthu komanso chilengedwe.Ndi zowonjezera zambiri zomwe zitha kugwiritsidwa ntchito m'mafakitale odzola, mankhwala, ndi zakudya.

Amagwiritsidwa ntchito mu cosmetology

1,3-Dihydroxyacetone imagwiritsidwa ntchito makamaka ngati mankhwala opangira zodzoladzola, makamaka ngati mafuta oteteza dzuwa omwe ali ndi zotsatira zapadera, zomwe zingalepheretse kutuluka kwakukulu kwa chinyezi cha khungu, ndikuthandizira kunyowetsa, kuteteza dzuwa, ndi chitetezo cha UV.Kuonjezera apo, magulu a ketone ogwira ntchito ku DHA amatha kuchitapo kanthu ndi amino acid ndi magulu amino a keratin a khungu kuti apange polima ya bulauni, zomwe zimapangitsa kuti khungu la anthu likhale ndi mtundu wa bulauni.Chifukwa chake, itha kugwiritsidwanso ntchito ngati chofananira kuti pakhale kuwala kwa dzuwa kuti mupeze khungu la bulauni kapena labulauni lomwe limawoneka lofanana ndi zotsatira za nthawi yayitali ya dzuwa, ndikupangitsa kuti liwoneke bwino.

Limbikitsani kuchuluka kwa nkhumba zowonda kwambiri

1,3-Dihydroxyacetone ndi chinthu chapakatikati cha kagayidwe ka shuga, chomwe chimagwira ntchito yofunika kwambiri pakupanga kagayidwe ka shuga, kuchepetsa mafuta a nkhumba ndikuwongolera kuchuluka kwa nyama yowonda.Ogwira ntchito za sayansi ndi zamakono a ku Japan asonyeza kupyolera mu kuyesa kuti kuwonjezera kuchuluka kwa DHA ndi kusakaniza kwa pyruvate (calcium salt) mu chakudya cha nkhumba (mu 3: 1 kulemera kwa chiŵerengero) kungachepetse mafuta a nkhumba ndi 12% 15%, ndipo mafuta omwe ali m'miyendo ndi minofu yayitali kwambiri yam'mbuyo amachepetsedwanso, ndikuwonjezeka kwa mapuloteni.

Kwa zakudya zinchito

Kuphatikizira 1,3-dihydroxyacetone (makamaka kuphatikiza ndi pyruvate) kumatha kusintha kagayidwe kachakudya m'thupi ndi mafuta acid oxidation, kumatha kuwotcha mafuta kuti muchepetse mafuta am'thupi ndikuchedwetsa kunenepa (kuchepetsa thupi), komanso kuchepetsa kuchuluka kwa matenda okhudzana.Ithanso kukulitsa chidwi cha insulin ndikuchepetsa kuchuluka kwa cholesterol m'magazi chifukwa cha zakudya zamafuta ambiri.Kuphatikizika kwa nthawi yayitali kumatha kukulitsa kuchuluka kwa shuga m'magazi ndikusunga minofu ya glycogen, Kwa othamanga, imatha kupititsa patsogolo kupirira kwawo kwa aerobic.

Ntchito zina

1,3-dihydroxyacetone itha kugwiritsidwanso ntchito mwachindunji ngati antiviral reagent.Mwachitsanzo, mu chikhalidwe cha mwana wosabadwayo wa nkhuku, kugwiritsa ntchito DHA kumatha kulepheretsa kwambiri matenda a nkhuku distemper virus, kupha 51% mpaka 100% ya kachilomboka.M'makampani achikopa, DHA ikhoza kugwiritsidwa ntchito ngati chitetezo chazinthu zachikopa.Kuphatikiza apo, zoteteza makamaka zopangidwa ndi DHA zitha kugwiritsidwa ntchito posungira ndi kusunga zipatso ndi ndiwo zamasamba, zam'madzi, ndi nyama.